this post was submitted on 04 Mar 2024
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[–] KittyBobo@hexbear.net 9 points 7 months ago (3 children)

I was thinking I want to just try antiandrogens with no other hormones, but DIY would be the only way I could do it.

[–] tactical_trans_karen@hexbear.net 12 points 7 months ago

That'll fuck up your health comrade, we need sex hormones for normal functioning.

[–] frankfurt_schoolgirl@hexbear.net 12 points 7 months ago (1 children)

If you don't mind me asking, what are your goals with this? People will say that the human body needs sex hormones to function and it's dangerous to have none. That's not completely true, like women after menopause have low sex hormones, historically eunuchs lives their whole lives with low sex hormones. But, long term it definitely raises the risk of stuff like osteoporosis. Short term, it will probably reduce your sex drive and possibly give you low energy levels of depression.

Anti androgens are the tricky part of transfem hrt. Maor of them have side effects, and the difference in Moses of action is confusing. Spironolactone is the most common AA in the US, but it's actually a fairly bad drug. You probably won't be able to completely block T with just Spiro, and if you do you'll have to take a high dose with issues. Finasteride might work better I think. There's also Bicalutamide and cyproterone acetate, which I believe carry more risks.

Also, diy AAs are somewhat expensive. Most people doing DIY just do high dose estrogen injections. This works because your testicles will reduce testosterone production with high estrogen levels, and with enough will basically stop doing anything. However, doctors are reluctant to do estrogen monotherapy because is usually requires estrogen levels that are higher than the "standard cis women levels".

[–] KittyBobo@hexbear.net 9 points 7 months ago (1 children)

I just wanted to try it out to see how I feel. I don't want breasts, some minor feminisation would be okay because I'm already a bit androgynous. I have been thinking about just being null/eunuch or whatever but I wanted to know what that would feel like and if that's what I truly want. As for the bone density or other health issues, let me ask you this: If all HRT gave you cancer or shortened your life by 10 years would it be worth it to transition or would you just stick with the dysphoria?

[–] AutomatedPossum@hexbear.net 8 points 7 months ago

The least side-effect heavy option would be to go with a GNRH antagonist like leuprorelin (that's the stuff that's commonly known as puberty blockers). These are often only prescribed to pre-transition kids because they're the most expensive choice, but they may be worth the cost if you can afford them. CPA or spiro should be taken with regular bloodwork to avoid damage to the liver (CPA) or the kidneys (spiro), and bica has a reputation of being less effective than these.

There's also SERMs (selective estrogen reuptake modulators) like tamoxifen which are normally used to treat mamacarcinoma, which could in theory be used to achieve feminizing HRT without breast growth. idk if these are actually in use for this kind of stuff, or if they're available through DIY HRT vendors, but maybe they are an option. I'd research them a lot more if i'd be interested in that kind of stuff, tho, they sound fairly heavy.

But i get where you're coming from and how you view potential risks, it's not as if conventional feminizing HRT 25 years ago would have been kinder on the body and i still would've done that if i would have already been cracked at that time.

[–] Outdoor_Catgirl@hexbear.net 9 points 7 months ago

Isn't that bad for bone density and stuff?